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Dynamic Regulation of α-Actinin’s Calponin Homology Domains on F-Actin
α-Actinin is an essential actin cross-linker involved in cytoskeletal organization and dynamics. The molecular conformation of α-actinin’s actin-binding domain (ABD) regulates its association with actin and thus mutations in this domain can lead to severe pathogenic conditions. A point mutation at l...
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| Veröffentlicht in: | Biophys J |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4816760/ https://ncbi.nlm.nih.gov/pubmed/27028653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.02.024 |
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