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α-Actinin Induces a Kink in the Transmembrane Domain of β(3)-Integrin and Impairs Activation via Talin
Integrin-mediated signaling is crucial for cell-substrate adhesion and can be triggered from both intra- and extracellular interactions. Although talin binding is sufficient for inside-out activation of integrin, other cytoplasmic proteins such as α-actinin and filamin can directly interfere with ta...
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| Veröffentlicht in: | Biophys J |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5567591/ https://ncbi.nlm.nih.gov/pubmed/28834730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.06.064 |
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