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α-Actinin Induces a Kink in the Transmembrane Domain of β(3)-Integrin and Impairs Activation via Talin

Integrin-mediated signaling is crucial for cell-substrate adhesion and can be triggered from both intra- and extracellular interactions. Although talin binding is sufficient for inside-out activation of integrin, other cytoplasmic proteins such as α-actinin and filamin can directly interfere with ta...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Shams, Hengameh, Mofrad, Mohammad R.K.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567591/
https://ncbi.nlm.nih.gov/pubmed/28834730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.06.064
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