Structural basis of the differential binding of engineered knottins to integrins αVβ3 and α5β1

Targeting both integrins αVβ3 and α5β1 simultaneously appears to be more effective in cancer therapy than targeting each one alone. The structural requirements for bispecific binding of ligand to integrins has not been fully elucidated. RGD-containing knottin 2.5F binds selectively to αVβ3 and α5β1,...

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Publicado no:Structure
Main Authors: Van Agthoven, Johannes F., Shams, Hengameh, Cochran, Frank V., Alonso, José L., Kintzing, James R., Garakani, Kiavash, Adair, Brian D., Xiong, Jian-Ping, Mofrad, Mohammad R. K., Cochran, Jennifer R., Arnaout, M. Amin
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726563/
https://ncbi.nlm.nih.gov/pubmed/31353240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.06.011
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