Structural basis of the differential binding of engineered knottins to integrins αVβ3 and α5β1

Targeting both integrins αVβ3 and α5β1 simultaneously appears to be more effective in cancer therapy than targeting each one alone. The structural requirements for bispecific binding of ligand to integrins has not been fully elucidated. RGD-containing knottin 2.5F binds selectively to αVβ3 and α5β1,...

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Détails bibliographiques
Publié dans:Structure
Auteurs principaux: Van Agthoven, Johannes F., Shams, Hengameh, Cochran, Frank V., Alonso, José L., Kintzing, James R., Garakani, Kiavash, Adair, Brian D., Xiong, Jian-Ping, Mofrad, Mohammad R. K., Cochran, Jennifer R., Arnaout, M. Amin
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726563/
https://ncbi.nlm.nih.gov/pubmed/31353240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.06.011
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