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The α-Subunit Regulates Stability of the Metal Ion at the Ligand-associated Metal Ion-binding Site in β(3) Integrins
The aspartate in the prototypical integrin-binding motif Arg-Gly-Asp binds the integrin βA domain of the β-subunit through a divalent cation at the metal ion-dependent adhesion site (MIDAS). An auxiliary metal ion at a ligand-associated metal ion-binding site (LIMBS) stabilizes the metal ion at MIDA...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132822/ https://ncbi.nlm.nih.gov/pubmed/24975416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581470 |
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