Atomic Basis for the Species-specific Inhibition of αV Integrins by Monoclonal Antibody 17E6 Is Revealed by the Crystal Structure of αVβ3 Ectodomain-17E6 Fab Complex

The function-blocking, non-RGD-containing, and primate-specific mouse monoclonal antibody 17E6 binds the αV subfamily of integrins. 17E6 is currently in phase II clinical trials for treating cancer. To elucidate the structural basis of recognition and the molecular mechanism of inhibition, we crysta...

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Detalhes bibliográficos
Main Authors: Mahalingam, Bhuvaneshwari, Van Agthoven, Johannes F., Xiong, Jian-Ping, Alonso, José Luis, Adair, Brian D., Rui, Xianliang, Anand, Saurabh, Mehrbod, Mehrdad, Mofrad, Mohammad R. K., Burger, Christa, Goodman, Simon L., Arnaout, M. Amin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022854/
https://ncbi.nlm.nih.gov/pubmed/24692540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.546929
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