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Three-dimensional EM structure of the ectodomain of integrin αVβ3 in a complex with fibronectin
Integrins are αβ heterodimeric cell surface receptors that mediate transmembrane signaling by binding extracellular and cytoplasmic ligands. The ectodomain of integrin αVβ3 crystallizes in a bent, genuflexed conformation considered to be inactive (unable to bind physiological ligands in solution) un...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171847/ https://ncbi.nlm.nih.gov/pubmed/15795319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200410068 |
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