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Crystal Structure of the Extracellular Segment of Integrin αVβ3

Integrins are αβ heterodimeric receptors that mediate divalent cation-dependent cell-cell and cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the crystal structure of the extracellular portion of integrin αVβ3 at 3.1 Å resolution. Its 12 domains assemble into...

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Detalhes bibliográficos
Main Authors: Xiong, Jian-Ping, Stehle, Thilo, Diefenbach, Beate, Zhang, Rongguang, Dunker, Reinhardt, Scott, David L., Joachimiak, Andrzej, Goodman, Simon L., Arnaout, M. Amin
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885948/
https://ncbi.nlm.nih.gov/pubmed/11546839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1064535
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