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Metal ion and ligand binding of integrin α(5)β(1)
Integrin α(5)β(1) binds to an Arg–Gly–Asp (RGD) motif in its ligand fibronectin. We report high-resolution crystal structures of a four-domain α(5)β(1) headpiece fragment, alone or with RGD peptides soaked into crystals, and RGD peptide affinity measurements. The headpiece crystallizes in a closed c...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4273411/ https://ncbi.nlm.nih.gov/pubmed/25475857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420645111 |
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