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β-Subunit Binding Is Sufficient for Ligands to Open the Integrin α(IIb)β(3) Headpiece
The platelet integrin α(IIb)β(3) binds to a KQAGDV motif at the fibrinogen γ-chain C terminus and to RGD motifs present in loops in many extracellular matrix proteins. These ligands bind in a groove between the integrin α and β-subunits; the basic Lys or Arg side chain hydrogen bonds to the α(IIb)-s...
Tallennettuna:
| Julkaisussa: | J Biol Chem |
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| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4813479/ https://ncbi.nlm.nih.gov/pubmed/26631735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705624 |
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