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Requirement of open headpiece conformation for activation of leukocyte integrin α(X)β(2)

Negative stain electron microscopy (EM) and adhesion assays show that α(X)β(2) integrin activation requires headpiece opening as well as extension. An extension-inducing Fab to the β(2) leg, in combination with representative activating and inhibitory Fabs, were examined for effect on the equilibriu...

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Main Authors: Chen, Xing, Xie, Can, Nishida, Noritaka, Li, Zongli, Walz, Thomas, Springer, Timothy A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930457/
https://ncbi.nlm.nih.gov/pubmed/20679211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008663107
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