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Requirement of open headpiece conformation for activation of leukocyte integrin α(X)β(2)
Negative stain electron microscopy (EM) and adhesion assays show that α(X)β(2) integrin activation requires headpiece opening as well as extension. An extension-inducing Fab to the β(2) leg, in combination with representative activating and inhibitory Fabs, were examined for effect on the equilibriu...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930457/ https://ncbi.nlm.nih.gov/pubmed/20679211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008663107 |
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