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Complete integrin headpiece opening in eight steps

Carefully soaking crystals with Arg-Gly-Asp (RGD) peptides, we captured eight distinct RGD-bound conformations of the α(IIb)β(3) integrin headpiece. Starting from the closed βI domain conformation, we saw six intermediate βI conformations and finally the fully open βI with the hybrid domain swung ou...

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Detalhes bibliográficos
Main Authors: Zhu, Jieqing, Zhu, Jianghai, Springer, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691460/
https://ncbi.nlm.nih.gov/pubmed/23798730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201212037
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