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Closed headpiece of integrin α(IIb)β(3) and its complex with an α(IIb)β(3)-specific antagonist that does not induce opening
The platelet integrin α(IIb)β(3) is essential for hemostasis and thrombosis through its binding of adhesive plasma proteins. We have determined crystal structures of the α(IIb)β(3) headpiece in the absence of ligand and after soaking in RUC-1, a novel small molecule antagonist. In the absence of lig...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012599/ https://ncbi.nlm.nih.gov/pubmed/20679525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-281154 |
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