Closed headpiece of integrin α(IIb)β(3) and its complex with an α(IIb)β(3)-specific antagonist that does not induce opening

The platelet integrin α(IIb)β(3) is essential for hemostasis and thrombosis through its binding of adhesive plasma proteins. We have determined crystal structures of the α(IIb)β(3) headpiece in the absence of ligand and after soaking in RUC-1, a novel small molecule antagonist. In the absence of lig...

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Autores principales: Zhu, Jieqing, Zhu, Jianghai, Negri, Ana, Provasi, Davide, Filizola, Marta, Coller, Barry S., Springer, Timothy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Vascular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012599/
https://ncbi.nlm.nih.gov/pubmed/20679525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-281154
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