Stable coordination of the inhibitory Ca(2+) ion at MIDAS in integrin CD11b/CD18 by an antibody-derived ligand aspartate: Implications for integrin regulation and structure-based drug design

A central feature of integrin interaction with physiologic ligands is the monodentate binding of a ligand carboxylate to a Mg(2+) ion hexacoordinated at the metal-ion-dependent-adhesion site (MIDAS) in the integrin A-domain. This interaction stabilizes the A-domain in the high-affinity state, which...

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Hlavní autoři: Mahalingam, Bhuvaneshwari, Ajroud, Kaouther, Alonso, Jose Luis, Anand, Saurabh, Adair, Brian, Horenstein, Alberto L, Malavasi, Fabio, Xiong, Jian-Ping, Arnaout, M. Amin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237904/
https://ncbi.nlm.nih.gov/pubmed/22095715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102394
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