Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors

Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA, kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor currents relieve cognitive deficits caused by neurodegenerative diseases such as Alzheimer's disease and show promise in t...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Jin, Rongsheng, Clark, Suzanne, Weeks, Autumn M., Dudman, Joshua T., Gouaux, Eric, Partin, Kathryn M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2005
Schlagworte:
Cellular/Molecular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725607/
https://ncbi.nlm.nih.gov/pubmed/16192394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2567-05.2005
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