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Structural and Functional Analysis of Two New Positive Allosteric Modulators of GluA2 Desensitization and Deactivation
At the dimer interface of the extracellular ligand-binding domain of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors a hydrophilic pocket is formed that is known to interact with two classes of positive allosteric modulators, represented by cyclothiazide and the ampakine 2H,3H,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3141890/ https://ncbi.nlm.nih.gov/pubmed/21543522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.070243 |
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