Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor

[Image: see text] The ionotropic glutamate receptor GluA2 is considered to be an attractive target for positive allosteric modulation for the development of pharmacological tools or cognitive enhancers. Here, we report a detailed structural characterization of two recently reported dimeric positive...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Laulumaa, Saara, Hansen, Kathrine Voigt, Masternak, Magdalena, Drapier, Thomas, Francotte, Pierre, Pirotte, Bernard, Frydenvang, Karla, Kastrup, Jette Sandholm
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421545/
https://ncbi.nlm.nih.gov/pubmed/30891120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00369
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