7-Phenoxy-substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

We report here the synthesis of 7-phenoxy-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides and their evaluation as AMPA receptor positive allosteric modulators (AMPApams). The impact of substitution on the phenoxy ring and on the nitrogen atom at the 4-position was examined. At GluA2(Q...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Goffin, Eric, Drapier, Thomas, Larsen, Anja Probst, Geubelle, Pierre, Ptak, Christopher P., Laulumaa, Saara, Rovinskaja, Karoline, Gilissen, Julie, de Tullio, Pascal, Olsen, Lars, Frydenvang, Karla, Pirotte, Bernard, Hanson, Julien, Oswald, Robert E., Kastrup, Jette Sandholm, Francotte, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052356/
https://ncbi.nlm.nih.gov/pubmed/29256599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01323
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