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The molecular mechanism of flop-selectivity and subsite recognition for an AMPA receptor allosteric modulator: Structures of GluA2 and GluA3 complexed with PEPA

Glutamate receptors are important potential drug targets for cognitive enhancement and the treatment of schizophrenia in part because they are the most prevalent excitatory neurotransmitter receptors in the vertebrate central nervous system. One approach to the application of therapeutic agents to t...

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Main Authors: Ahmed, Ahmed H., Ptak, Christopher P., Oswald, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072023/
https://ncbi.nlm.nih.gov/pubmed/20199107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1000678
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