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Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors

Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA, kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor currents relieve cognitive deficits caused by neurodegenerative diseases such as Alzheimer's disease and show promise in t...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Jin, Rongsheng, Clark, Suzanne, Weeks, Autumn M., Dudman, Joshua T., Gouaux, Eric, Partin, Kathryn M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725607/
https://ncbi.nlm.nih.gov/pubmed/16192394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2567-05.2005
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