Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors

Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA, kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor currents relieve cognitive deficits caused by neurodegenerative diseases such as Alzheimer's disease and show promise in t...

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Vydáno v:J Neurosci
Hlavní autoři: Jin, Rongsheng, Clark, Suzanne, Weeks, Autumn M., Dudman, Joshua T., Gouaux, Eric, Partin, Kathryn M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2005
Témata:
Cellular/Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725607/
https://ncbi.nlm.nih.gov/pubmed/16192394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2567-05.2005
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