The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance

Advanced bladder cancer (BCa) remains a major source of mortality, with poor treatment options. Cisplatin based chemotherapy is the standard treatment, however many patients are or become resistant. One potential cause of chemoresistance is the Warburg Effect, a metabolic switch to aerobic glycolysi...

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發表在:Mol Cancer Ther
Main Authors: Woolbright, Benjamin L., Choudhary, Dharamainder, Mikhalyuk, Andrew, Trammel, Cassandra, Shanmugam, Sambantham, Abbott, Erika, Pilbeam, Carol C., Taylor, John A.
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724734/
https://ncbi.nlm.nih.gov/pubmed/29907593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0063
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