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PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy

RATIONALE: Pregnancy profoundly alters maternal physiology. The heart hypertrophies during pregnancy, but its metabolic adaptations are not well understood. OBJECTIVE: To determine the mechanisms underlying cardiac substrate use during pregnancy. METHODS AND RESULTS: We use here (13)C-glucose, (13)C...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Liu, Laura X., Rowe, Glenn C., Yang, Steven, Li, Jian, Damilano, Federico, Chan, Mun Chun, Lu, Wenyun, Jang, Cholsoon, Wada, Shogo, Morley, Michael, Hesse, Michael, Fleischmann, Bernd K., Rabinowitz, Joshua D., Das, Saumya, Rosenzweig, Anthony, Arany, Zoltan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722682/
https://ncbi.nlm.nih.gov/pubmed/28928113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311456
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