PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy

RATIONALE: Pregnancy profoundly alters maternal physiology. The heart hypertrophies during pregnancy, but its metabolic adaptations are not well understood. OBJECTIVE: To determine the mechanisms underlying cardiac substrate use during pregnancy. METHODS AND RESULTS: We use here (13)C-glucose, (13)C...

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Udgivet i:Circ Res
Main Authors: Liu, Laura X., Rowe, Glenn C., Yang, Steven, Li, Jian, Damilano, Federico, Chan, Mun Chun, Lu, Wenyun, Jang, Cholsoon, Wada, Shogo, Morley, Michael, Hesse, Michael, Fleischmann, Bernd K., Rabinowitz, Joshua D., Das, Saumya, Rosenzweig, Anthony, Arany, Zoltan
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722682/
https://ncbi.nlm.nih.gov/pubmed/28928113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311456
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