PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy

RATIONALE: Pregnancy profoundly alters maternal physiology. The heart hypertrophies during pregnancy, but its metabolic adaptations are not well understood. OBJECTIVE: To determine the mechanisms underlying cardiac substrate use during pregnancy. METHODS AND RESULTS: We use here (13)C-glucose, (13)C...

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Gepubliceerd in:Circ Res
Hoofdauteurs: Liu, Laura X., Rowe, Glenn C., Yang, Steven, Li, Jian, Damilano, Federico, Chan, Mun Chun, Lu, Wenyun, Jang, Cholsoon, Wada, Shogo, Morley, Michael, Hesse, Michael, Fleischmann, Bernd K., Rabinowitz, Joshua D., Das, Saumya, Rosenzweig, Anthony, Arany, Zoltan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722682/
https://ncbi.nlm.nih.gov/pubmed/28928113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311456
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