The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance

Advanced bladder cancer (BCa) remains a major source of mortality, with poor treatment options. Cisplatin based chemotherapy is the standard treatment, however many patients are or become resistant. One potential cause of chemoresistance is the Warburg Effect, a metabolic switch to aerobic glycolysi...

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Détails bibliographiques
Publié dans:Mol Cancer Ther
Auteurs principaux: Woolbright, Benjamin L., Choudhary, Dharamainder, Mikhalyuk, Andrew, Trammel, Cassandra, Shanmugam, Sambantham, Abbott, Erika, Pilbeam, Carol C., Taylor, John A.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724734/
https://ncbi.nlm.nih.gov/pubmed/29907593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0063
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