The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance

Advanced bladder cancer (BCa) remains a major source of mortality, with poor treatment options. Cisplatin based chemotherapy is the standard treatment, however many patients are or become resistant. One potential cause of chemoresistance is the Warburg Effect, a metabolic switch to aerobic glycolysi...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Woolbright, Benjamin L., Choudhary, Dharamainder, Mikhalyuk, Andrew, Trammel, Cassandra, Shanmugam, Sambantham, Abbott, Erika, Pilbeam, Carol C., Taylor, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724734/
https://ncbi.nlm.nih.gov/pubmed/29907593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0063
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