Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin

The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate to acetyl-CoA in mitochondria and is a key regulatory enzyme in the oxidation of glucose to acetyl-CoA. Phosphorylation of PDC by the pyruvate dehydrogenase kinases (PDK) inhibits its activity. The expression of the pyruva...

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Detalhes bibliográficos
Main Authors: Connaughton, Sara, Chowdhury, Farhana, Attia, Ramy R., Song, Shulan, Zhang, Yi, Elam, Marshall B., Cook, George A., Park, Edwards A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2815206/
https://ncbi.nlm.nih.gov/pubmed/19703515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2009.08.011
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