Tumor cell–intrinsic EPHA2 suppresses antitumor immunity by regulating PTGS2 (COX-2)

Resistance to immunotherapy is one of the biggest problems of current oncotherapeutics. While T cell abundance is essential for tumor responsiveness to immunotherapy, factors that define the T cell–inflamed tumor microenvironment are not fully understood. We used an unbiased approach to identify tum...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Markosyan, Nune, Li, Jinyang, Sun, Yu H., Richman, Lee P., Lin, Jeffrey H., Yan, Fangxue, Quinones, Liz, Sela, Yogev, Yamazoe, Taiji, Gordon, Naomi, Tobias, John W., Byrne, Katelyn T., Rech, Andrew J., FitzGerald, Garret A., Stanger, Ben Z., Vonderheide, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715369/
https://ncbi.nlm.nih.gov/pubmed/31162144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127755
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