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Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions(1),(2)
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H(2), the precursor of the major prostanoids. To address the functional interchangeability of these two isoforms and their distinct roles, we ha...
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| Publicado no: | J Lipid Res |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748500/ https://ncbi.nlm.nih.gov/pubmed/29180445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M079996 |
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