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Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice(1),(2)
Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function coordinately during inflammation. But the relative contributions and compensations of COX-1 and COX-2 to inflammatory responses remain unanswered. We used three engineered mouse lines where the Ptgs1 and Ptgs2 genes substitu...
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| Publicado en: | J Lipid Res |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Biochemistry and Molecular Biology
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748501/ https://ncbi.nlm.nih.gov/pubmed/29180443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M080028 |
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