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Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice(1),(2)

Both cyclooxygenase (COX)-1 and COX-2, encoded by Ptgs1 and Ptgs2, function coordinately during inflammation. But the relative contributions and compensations of COX-1 and COX-2 to inflammatory responses remain unanswered. We used three engineered mouse lines where the Ptgs1 and Ptgs2 genes substitu...

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Detaylı Bibliyografya
Yayımlandı:J Lipid Res
Asıl Yazarlar: Li, Xinzhi, Mazaleuskaya, Liudmila L., Ballantyne, Laurel L., Meng, Hu, FitzGerald, Garret A., Funk, Colin D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Biochemistry and Molecular Biology 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748501/
https://ncbi.nlm.nih.gov/pubmed/29180443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M080028
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