Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions(1),(2)

Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H(2), the precursor of the major prostanoids. To address the functional interchangeability of these two isoforms and their distinct roles, we ha...

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Bibliografiske detaljer
Udgivet i:J Lipid Res
Main Authors: Li, Xinzhi, Mazaleuskaya, Liudmila L., Yuan, Chong, Ballantyne, Laurel L., Meng, Hu, Smith, William L., FitzGerald, Garret A., Funk, Colin D.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748500/
https://ncbi.nlm.nih.gov/pubmed/29180445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M079996
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