COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancer in two independent populations

PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) target the prostaglandin H synthase enzymes, cyclooxygenase (COX)-1 and -2, and reduce colorectal cancer risk. Genetic variation in the genes encoding these enzymes may be associated with changes in colon and rectal cancer risk and in NSAID effi...

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Hlavní autoři: Makar, Karen W, Poole, Elizabeth M, Resler, Alexa J, Seufert, Brenna, Curtin, Karen, Kleinstein, Sarah E, Duggan, David, Kulmacz, Richard J, Hsu, Li, Whitton, John, Carlson, Christopher S, Rimorin, Christine F, Caan, Bette J, Baron, John A, Potter, John D, Slattery, Martha L, Ulrich, Cornelia M
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913564/
https://ncbi.nlm.nih.gov/pubmed/24022467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10552-013-0282-1
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