COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancer in two independent populations

PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) target the prostaglandin H synthase enzymes, cyclooxygenase (COX)-1 and -2, and reduce colorectal cancer risk. Genetic variation in the genes encoding these enzymes may be associated with changes in colon and rectal cancer risk and in NSAID effi...

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Detalhes bibliográficos
Main Authors: Makar, Karen W, Poole, Elizabeth M, Resler, Alexa J, Seufert, Brenna, Curtin, Karen, Kleinstein, Sarah E, Duggan, David, Kulmacz, Richard J, Hsu, Li, Whitton, John, Carlson, Christopher S, Rimorin, Christine F, Caan, Bette J, Baron, John A, Potter, John D, Slattery, Martha L, Ulrich, Cornelia M
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913564/
https://ncbi.nlm.nih.gov/pubmed/24022467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10552-013-0282-1
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