Small-molecule targeting hairpin loop of hTERT promoter G-quadruplex induces cancer cell death

Increased telomerase activity is associated with malignancy and poor prognosis in human cancer, but the development of targeted agents has not yet provided clinical benefit. Here we report that, instead of targeting the telomerase enzyme directly, small molecules that bind to the G-hairpin of the hT...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Song, Jin H., Kang, Hyun-Jin, Luevano, Libia A., Gokhale, Vijay, Wu, Kui, Pandey, Ritu, Chow, H.-H. Sherry, Hurley, Laurence H., Kraft, Andrew S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713458/
https://ncbi.nlm.nih.gov/pubmed/31155510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.04.009
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge