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Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands

The hTERT core promoter contains a G-rich region of 12 consecutive G-tracts, embracing three Sp1 binding sites, and has the potential to form multiple G-quadruplexes. From the 12 runs of guanine tracts, 9 putative hTERT G-quadruplex-forming sequences were selected to assay for G-quadruplex formation...

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Detalhes bibliográficos
Main Authors: Palumbo, SunMi L., Ebbinghaus, Scot W., Hurley, Laurence H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761083/
https://ncbi.nlm.nih.gov/pubmed/19601575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja902281d
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