Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion

Transcriptional activation of the human telomerase reverse transcriptase (hTERT) gene, which remains repressed in adult somatic cells, is critical during tumorigenesis. Several transcription factors and the epigenetic state of the hTERT promoter are known to be important for tight control of hTERT i...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Saha, Dhurjhoti, Singh, Ankita, Hussain, Tabish, Srivastava, Vivek, Sengupta, Suman, Kar, Anirban, Dhapola, Parashar, Dhople, Vishnu, Ummanni, Ramesh, Chowdhury, Shantanu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602382/
https://ncbi.nlm.nih.gov/pubmed/28717007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792077
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