Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion

Transcriptional activation of the human telomerase reverse transcriptase (hTERT) gene, which remains repressed in adult somatic cells, is critical during tumorigenesis. Several transcription factors and the epigenetic state of the hTERT promoter are known to be important for tight control of hTERT i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Saha, Dhurjhoti, Singh, Ankita, Hussain, Tabish, Srivastava, Vivek, Sengupta, Suman, Kar, Anirban, Dhapola, Parashar, Dhople, Vishnu, Ummanni, Ramesh, Chowdhury, Shantanu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Gene Regulation
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602382/
https://ncbi.nlm.nih.gov/pubmed/28717007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792077
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