Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion

Transcriptional activation of the human telomerase reverse transcriptase (hTERT) gene, which remains repressed in adult somatic cells, is critical during tumorigenesis. Several transcription factors and the epigenetic state of the hTERT promoter are known to be important for tight control of hTERT i...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Saha, Dhurjhoti, Singh, Ankita, Hussain, Tabish, Srivastava, Vivek, Sengupta, Suman, Kar, Anirban, Dhapola, Parashar, Dhople, Vishnu, Ummanni, Ramesh, Chowdhury, Shantanu
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602382/
https://ncbi.nlm.nih.gov/pubmed/28717007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792077
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