Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion

Transcriptional activation of the human telomerase reverse transcriptase (hTERT) gene, which remains repressed in adult somatic cells, is critical during tumorigenesis. Several transcription factors and the epigenetic state of the hTERT promoter are known to be important for tight control of hTERT i...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Saha, Dhurjhoti, Singh, Ankita, Hussain, Tabish, Srivastava, Vivek, Sengupta, Suman, Kar, Anirban, Dhapola, Parashar, Dhople, Vishnu, Ummanni, Ramesh, Chowdhury, Shantanu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2017
Konular:
Gene Regulation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602382/
https://ncbi.nlm.nih.gov/pubmed/28717007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.792077
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