An Improved Model for the hTERT Promoter Quadruplex

Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadrupl...

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Bibliographic Details
Published in:PLoS One
Main Authors: Chaires, Jonathan B., Trent, John O., Gray, Robert D., Dean, William L., Buscaglia, Robert, Thomas, Shelia D., Miller, Donald M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272262/
https://ncbi.nlm.nih.gov/pubmed/25526084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115580
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