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Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing

Ligand 12459, a potent G-quadruplex-interacting agent that belongs to the triazine series, was previously shown to downregulate telomerase activity in the human A549 lung carcinoma cell line. We show here that the downregulation of telomerase activity is caused by an alteration of the hTERT splicing...

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Bibliografische gegevens
Hoofdauteurs: Gomez, Dennis, Lemarteleur, Thibault, Lacroix, Laurent, Mailliet, Patrick, Mergny, Jean-Louis, Riou, Jean-François
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2004
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC373291/
https://ncbi.nlm.nih.gov/pubmed/14729921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh181
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