Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

The telomeric G-rich single-stranded DNA can adopt in vitro an intramolecular quadruplex structure, which has been shown to directly inhibit telomerase activity. The reactivation of this enzyme in immortalized and most cancer cells suggests that telomerase is a relevant target in oncology, and telom...

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Dades bibliogràfiques

Publicat a:	Nucleic Acids Res
Autors principals:	Koeppel, Florence, Riou, Jean-François, Laoui, Abdelazize, Mailliet, Patrick, Arimondo, Paola B., Labit, Delphine, Petitgenet, Odile, Hélène, Claude, Mergny, Jean-Louis
Format:	Artigo
Idioma:	Inglês
Publicat:	Oxford University Press 2001
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29720/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222758/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.5.1087
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