Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing

Ligand 12459, a potent G-quadruplex-interacting agent that belongs to the triazine series, was previously shown to downregulate telomerase activity in the human A549 lung carcinoma cell line. We show here that the downregulation of telomerase activity is caused by an alteration of the hTERT splicing...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Gomez, Dennis, Lemarteleur, Thibault, Lacroix, Laurent, Mailliet, Patrick, Mergny, Jean-Louis, Riou, Jean-François
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 2004
Assuntos:	Articles
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373291/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14729921/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh181
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