Small-molecule targeting hairpin loop of hTERT promoter G-quadruplex induces cancer cell death

Increased telomerase activity is associated with malignancy and poor prognosis in human cancer, but the development of targeted agents has not yet provided clinical benefit. Here we report that, instead of targeting the telomerase enzyme directly, small molecules that bind to the G-hairpin of the hT...

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Udgivet i:Cell Chem Biol
Main Authors: Song, Jin H., Kang, Hyun-Jin, Luevano, Libia A., Gokhale, Vijay, Wu, Kui, Pandey, Ritu, Chow, H.-H. Sherry, Hurley, Laurence H., Kraft, Andrew S.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713458/
https://ncbi.nlm.nih.gov/pubmed/31155510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.04.009
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