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Small-molecule targeting hairpin loop of hTERT promoter G-quadruplex induces cancer cell death
Increased telomerase activity is associated with malignancy and poor prognosis in human cancer, but the development of targeted agents has not yet provided clinical benefit. Here we report that, instead of targeting the telomerase enzyme directly, small molecules that bind to the G-hairpin of the hT...
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| Pubblicato in: | Cell Chem Biol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6713458/ https://ncbi.nlm.nih.gov/pubmed/31155510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.04.009 |
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