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G-Quadruplex-Mediated Transcriptional Regulation of PDGFR-β
G-quadruplexes (four-stranded DNA secondary structures) are showing promise as new targets for anticancer therapies. Specifically, G-quadruplexes in the proximal promoter region of regulatory genes have the potential to act as silencer elements and thereby turn off transcription. Thus, compounds tha...
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| Veröffentlicht in: | Top Curr Chem |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4247186/ https://ncbi.nlm.nih.gov/pubmed/22752577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/128_2012_333 |
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