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Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design

Unimolecular parallel-stranded G-quadruplex structures are found to be prevalent in gene promoters. The nuclease hypersensitivity element III(1) (NHE III(1)) of the c-MYC promoter can form transcriptionally active and silenced forms and the formation of DNA G-quadruplex structures has been shown to...

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Библиографические подробности
Главные авторы: Dai, Jixun, Carver, Megan, Hurley, Laurence H., Yang, Danzhou
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207019/
https://ncbi.nlm.nih.gov/pubmed/21967482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205646q
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