Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex

Most transcription of the MYC proto-oncogene initiates in the near upstream promoter, within which lies the nuclease hypersensitive element (NHE) III(1) region containing the CT-element. This dynamic stretch of DNA can form at least three different topologies: single-stranded DNA, double-stranded DN...

Full description

Saved in:
Bibliographic Details
Main Authors: Brown, Robert V., Danford, Forest L., Gokhale, Vijay, Hurley, Laurence H., Brooks, Tracy A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220475/
https://ncbi.nlm.nih.gov/pubmed/21956115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274720
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items