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Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations

Nonsynonymous gene mutations can be beneficial, neutral, or detrimental to the stability, structure, and biological function of the encoded protein, but the effects of these mutations are often not readily predictable. For example, the β-propeller olfactomedin domain of myocilin (mOLF) exhibits a co...

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書目詳細資料
發表在:J Biol Chem
Main Authors: Hill, Shannon E., Kwon, Michelle S., Martin, Mackenzie D., Suntharalingam, Amirthaa, Hazel, Anthony, Dickey, Chad A., Gumbart, James C., Lieberman, Raquel L.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709634/
https://ncbi.nlm.nih.gov/pubmed/31270212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009419
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