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The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence

The glaucoma-associated olfactomedin domain of myocilin (myoc-OLF) is a recent addition to the growing list of disease-associated amyloidogenic proteins. Inherited, diseasecausing myocilin variants aggregate intracellularly instead of being secreted to the trabecular meshwork (TM), which is a scenar...

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Bibliografiske detaljer
Main Authors: Hill, Shannon E., Donegan, Rebecca K., Lieberman, Raquel L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946817/
https://ncbi.nlm.nih.gov/pubmed/24333014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.12.002
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