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The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence
The glaucoma-associated olfactomedin domain of myocilin (myoc-OLF) is a recent addition to the growing list of disease-associated amyloidogenic proteins. Inherited, diseasecausing myocilin variants aggregate intracellularly instead of being secreted to the trabecular meshwork (TM), which is a scenar...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3946817/ https://ncbi.nlm.nih.gov/pubmed/24333014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.12.002 |
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