The domain architecture of the protozoan protein J-DNA–binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity

J-DNA–binding protein 1 (JBP1) contributes to the biosynthesis and maintenance of base J (β-d-glucosyl-hydroxymethyluracil), an epigenetic modification of thymidine (T) confined to pathogenic protozoa such as Trypanosoma and Leishmania. JBP1 has two known functional domains: an N-terminal T hydroxyl...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Adamopoulos, Athanassios, Heidebrecht, Tatjana, Roosendaal, Jeroen, Touw, Wouter G., Phan, Isabelle Q., Beijnen, Jos, Perrakis, Anastassis
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709619/
https://ncbi.nlm.nih.gov/pubmed/31292194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007393
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