The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans.

DNA from Kinetoplastida contains the unusual modified base beta-D-glucosyl(hydroxymethyl)uracil, called J. Base J is found predominantly in repetitive DNA and correlates with epigenetic silencing of telomeric variant surface glycoprotein genes in Trypanosoma brucei. We have now identified a protein...

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Main Authors: Cross, M, Kieft, R, Sabatini, R, Wilm, M, de Kort, M, van der Marel, G A, van Boom, J H, van Leeuwen, F, Borst, P
Formato: Artigo
Idioma:Inglês
Publicado: 1999
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171720/
https://ncbi.nlm.nih.gov/pubmed/10562569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6573
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