Combining Isotopic Tracer Techniques to Increase Efficiency of Clinical Pharmacokinetic Trials in Oncology

Por Roosendaal, Jeroen, Rosing, Hilde, Beijnen, Jos H.
Publicado no Drugs R D (2020)

Stable Isotopically Labeled Intravenous Microdose Pharmacokinetic Trials as a Tool to Assess Absolute Bioavailability: Feasibility and Paradigm to Apply for Protein Kinase Inhibito...

Por Roosendaal, Jeroen, Rosing, Hilde, Beijnen, Jos H.
Publicado no Clin Pharmacol Drug Dev (2020)

The domain architecture of the protozoan protein J-DNA–binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity

Por Adamopoulos, Athanassios, Heidebrecht, Tatjana, Roosendaal, Jeroen, Touw, Wouter G., Phan, Isabelle Q., Beijnen, Jos, Perrakis, Anastassis
Publicado no J Biol Chem (2019)

Mass balance and metabolite profiling of (14)C-guadecitabine in patients with advanced cancer

Por Roosendaal, Jeroen, Rosing, Hilde, Lucas, Luc, Gebretensae, Abadi, Huitema, Alwin D. R., van Dongen, Marloes G., Beijnen, Jos H., Oganesian, Aram
Publicado no Invest New Drugs (2019)

Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose

Por Roosendaal, Jeroen, Groenland, Stefanie L., Rosing, Hilde, Lucas, Luc, Venekamp, Nikkie, Nuijen, Bastiaan, Huitema, Alwin D. R., Beijnen, Jos H., Steeghs, Neeltje
Publicado no Eur J Clin Pharmacol (2020)

3′-Phosphoadenosine 5′-phosphosulfate synthase 1 (PAPSS1) knockdown sensitizes non-small cell lung cancer cells to DNA damaging agents

Por Leung, Ada W. Y., Dragowska, Wieslawa H., Ricaurte, Daniel, Kwok, Brian, Mathew, Veena, Roosendaal, Jeroen, Ahluwalia, Amith, Warburton, Corinna, Laskin, Janessa J., Stirling, Peter C., Qadir, Mohammed A., Bally, Marcel B.
Publicado no Oncotarget (2015)

Phase I pharmacological study of continuous chronomodulated capecitabine treatment

Por Roosendaal, Jeroen, Jacobs, Bart A. W., Pluim, Dick, Rosing, Hilde, de Vries, Niels, van Werkhoven, Erik, Nuijen, Bastiaan, Beijnen, Jos H., Huitema, Alwin D. R., Schellens, Jan H. M., Marchetti, Serena
Publicado no Pharm Res (2020)